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Maxfield's enhanced ripper-werewolf virus into Elena's body, infecting her.
Elena's friends are eventually able to find an antidote.
During a confrontation with Katherine, Elena shoves the cure down Katherine's throat, forcing her to become human again.
In season five, Elena starts at Whitmore College after spending the summer with Damon.
In season two, she learns that she is a Petrova doppelgänger, exactly resembling Katherine Pierce, which means that she can be sacrificed to release Klaus' werewolf side.In the season two finale, while Damon is dying from a werewolf bite, she forgives him for forcing her to drink his blood and kisses him. However, in order to convince Klaus to give his blood to Damon, Stefan had to turn into his "Ripper" self and accompany Klaus.In season three, Elena does everything in her power to make Stefan regain his humanity, which he switched off to satisfy, and tolerate, Klaus.She grows closer to Damon while working together to save Stefan and try to defeat Klaus, eventually sharing a kiss.
She later admits to Stefan that she has feelings for Damon as well, but that she never stopped loving Stefan.
It is eventually revealed that Elena met Damon the night of her parents' death, though he compelled her to forget.